Spatially resolved genome-wide joint profiling of epigenome and transcriptome with spatial-ATAC-RNA-seq and spatial-CUT&Tag-RNA-seq
Li H, Bao S, Farzad N, Qin X, Fung A, Zhang D, Bai Z, Tao B, Fan R. Spatially resolved genome-wide joint profiling of epigenome and transcriptome with spatial-ATAC-RNA-seq and spatial-CUT&Tag-RNA-seq. Nature Protocols 2025, 20: 2383-2417. PMID: 40119005, DOI: 10.1038/s41596-025-01145-9.Peer-Reviewed Original ResearchNear single-cell resolutionControl cell identityTargeting histone modificationsSingle-cell resolutionTn5 transposaseAccessible chromatinEpigenomic landscapeIn situ reverse transcriptionHistone modificationsCell identityTranscriptomic landscapeSequencing protocolSequencing methodsGene transcriptionEpigenomeOligonucleotide barcodesTranscriptomeDiverse biological activitiesIntact tissue sectionsReverse transcriptionTranscriptionBiological activityPrimary antibodyTagmentationTissue pixels
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