2025
Autosomal Dominant Polycystic Kidney Disease
Chebib F, Hanna C, Harris P, Torres V, Dahl N. Autosomal Dominant Polycystic Kidney Disease. JAMA 2025, 333: 1708-1719. PMID: 40126492, DOI: 10.1001/jama.2025.0310.Peer-Reviewed Original ResearchMeSH KeywordsAdultAneurysm, RupturedAntidiuretic Hormone Receptor AntagonistsDisease ProgressionGlomerular Filtration RateHumansHypertensionIntracranial AneurysmKidneyPolycystic Kidney, Autosomal DominantRenal Insufficiency, ChronicRenal Replacement TherapySeverity of Illness IndexTolvaptanTreatment OutcomeTRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseMayo imaging classificationRate of eGFR declineKidney replacement therapyEGFR declineDevelopment of kidney cystsKidney diseaseKidney failureReplacement therapyMm HgVasopressin type 2 receptor antagonist tolvaptanProgression to kidney replacement therapyAnnual rate of eGFR declineAdequate hydrationIntracranial aneurysmsManagement of Autosomal Dominant Polycystic Kidney DiseaseWeight managementProgression to kidney failureDietary sodium restrictionFirst-line treatmentKidney cystsSeverity of kidney diseaseTotal kidney volumeDominant polycystic kidney diseaseDe novo disease
2024
Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV
Pelchen-Matthews A, Mocroft A, Ryom L, Ross M, Sharma S, Coca S, Achhra A, Cornell E, Tracy R, Phillips A, Alonso M, Toulomi G, Agan B, Medland N, Wyatt C, Group I. Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV. Kidney International 2024, 106: 136-144. PMID: 38697479, PMCID: PMC11193627, DOI: 10.1016/j.kint.2024.04.010.Peer-Reviewed Original ResearchHuman immunodeficiency virusUrine albumin/creatinine ratioDeferred antiretroviral therapyChronic kidney diseaseStrategic Timing of AntiRetroviral TreatmentAntiretroviral therapyNo significant differenceTreatment armsFollow-upAnnual rate of eGFR declineRate of eGFR declineTiming of AntiRetroviral TreatmentEarly ARTART-naive adultsCD4 cell countImmediate antiretroviral therapySignificant differenceKidney-related deathLong-term safetyKidney healthStandard of careComprehensive follow-upImmunodeficiency virusAlbumin/creatinine ratioEGFR decline
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