Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine
Cui Z, Gorelick F, Dannies P. Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine. Endocrinology 1994, 134: 2245-2250. DOI: 10.1210/en.134.5.2245.Peer-Reviewed Original ResearchInhibit PRL releasePRL releaseCaM kinase-IIPulse of TRHPituitary cellsTRH-induced PRL releaseIntracellular Ca2+ concentrationCalcium/calmodulin-dependent protein kinase-IIResponse to TRHRat pituitary cellsTRH-induced increaseAnterior pituitary cellsPresence of thyrotropin-releasing hormoneThyrotropin-releasing hormoneCa2+ concentrationKinase activityPretreatment of cellsRat lactotrophsTRH pulsesBasal valuesTRHDopamineLactotrophsDown-regulationPRL
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