The microbiota regulate neuronal function and fear extinction learning
Chu C, Murdock M, Jing D, Won T, Chung H, Kressel A, Tsaava T, Addorisio M, Putzel G, Zhou L, Bessman N, Yang R, Moriyama S, Parkhurst C, Li A, Meyer H, Teng F, Chavan S, Tracey K, Regev A, Schroeder F, Lee F, Liston C, Artis D. The microbiota regulate neuronal function and fear extinction learning. Nature 2019, 574: 543-548. PMID: 31645720, PMCID: PMC6818753, DOI: 10.1038/s41586-019-1644-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAutistic DisorderBloodCalciumCerebrospinal FluidCuesDendritic SpinesExtinction, PsychologicalFearFecesGerm-Free LifeIndicanMaleMetabolomicsMiceMice, Inbred BALB CMice, Inbred C57BLMicrobiotaNeural InhibitionNeurogliaNeuronsPhenylpropionatesPrefrontal CortexSchizophreniaTranscriptomeVagus NerveConceptsFear extinction learningMedial prefrontal cortexExtinction learningMicrobiota-derived signalsPrefrontal cortexNeuropsychiatric disordersAdult miceSusceptibility to neuropsychiatric disordersInfluence many physiological processesGerm-free adult miceTranscranial two-photon imagingMicrobiota-derived compoundsSingle-nucleus RNA sequencingGerm-free miceComplex consortiaMulticellular organismsPostsynaptic dendritic spinesBrain healthBrain functionRNA sequencingMicrobiotaIn adulthoodGene expressionNeuronal activityPostnatal neurodevelopment
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