PD-1 signaling impacts T cell function during the early phase of infection with Toxoplasma gondii
Perry J, Delong J, Clark J, Park J, Gullicksrud J, Shallberg L, Konradt C, Christian D, Hunter C. PD-1 signaling impacts T cell function during the early phase of infection with Toxoplasma gondii. The Journal Of Immunology 2019, 202: 122.5-122.5. DOI: 10.4049/jimmunol.202.supp.122.5.Peer-Reviewed Original ResearchCD8+ T cellsPD-1 signalingPhase of infectionPD-1T cellsEarly phase of infectionPD-L1Inhibitory receptorsProportion of activated CD8+ T cellsExpression of multiple inhibitory receptorsPolyfunctional CD8+ T cellsCD8+ T cell responsesCD8+ T cell populationsTerminally differentiated T cellsExpression of inhibitory receptorsInfected CD8+ T cellsT cell effector differentiationProduction of IFN-gReduced parasite burdenIncreased immune pathologyMultiple inhibitory receptorsPD-L1 blockadeLigand PD-L1T cell responsesT cell populations
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