2025
SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses
Nehar-Belaid D, Mejías A, Xu Z, Marches R, Yerrabelli R, Chen G, Mertz S, Ye F, Sánchez P, Tsang J, Aydillo T, Miorin L, Cupic A, García-Sastre A, Ucar D, Banchereau J, Pascual V, Ramilo O. SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults’ responses. Nature Communications 2025, 16: 4562. PMID: 40379618, PMCID: PMC12084365, DOI: 10.1038/s41467-025-59411-z.Peer-Reviewed Original ResearchConceptsResponse to SARS-CoV-2Infected infantsT cellsSARS-CoV-2B cellsCytotoxic CD8+ T cellsImmune profile of childrenISG signatureNaive CD4+ T cellsCD8+ T cellsCD4+ T cellsImmune response to SARS-CoV-2Anti-IFN autoantibodiesAntibody response to SARS-CoV-2Transitional B cellsEarly life immunityCD14+ monocytesIncreased serum concentrationsInflammasome-related moleculesInterferon-stimulated genesImmune profileImmune perturbationsSerum concentrationsInflammatory cytokinesImmune response
2015
Limits and patterns of cytomegalovirus genomic diversity in humans
Renzette N, Pokalyuk C, Gibson L, Bhattacharjee B, Schleiss M, Hamprecht K, Yamamoto A, Mussi-Pinhata M, Britt W, Jensen J, Kowalik T. Limits and patterns of cytomegalovirus genomic diversity in humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4120-e4128. PMID: 26150505, PMCID: PMC4522815, DOI: 10.1073/pnas.1501880112.Peer-Reviewed Original ResearchConceptsGenomic diversityHuman hostGenome-wide mutationsHuman cytomegalovirusRecombination rate mapsHCMV populationsViral genomic diversityGenome beingRegulatory proteinsViral populationsDiversityPolymorphismHostPatient samplesDiverse regionsGenomeNatural infectionLociCongenitally infected infantsGenesMutationsProteinInfected infantsGlycoproteinRecombination
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