2025
QuANTUM-Wild: A phase 3, randomized, double-blind, placebo-controlled trial of quizartinib in combination with chemotherapy and as single-agent maintenance in FLT3 -ITD–negative acute myeloid leukemia (AML).
Montesinos P, Cheong J, Daver N, Fathi A, Levis M, Luger S, Miyamoto T, Oliva E, Perl A, Recher C, Schlenk R, Wang J, Zeidan A, Liu L, Duong Y, Imadalou K, Alexis K, Nahar A, Burns K, Erba H. QuANTUM-Wild: A phase 3, randomized, double-blind, placebo-controlled trial of quizartinib in combination with chemotherapy and as single-agent maintenance in FLT3 -ITD–negative acute myeloid leukemia (AML). Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.tps6580.Peer-Reviewed Original ResearchAcute myeloid leukemiaRelapse-free survivalEvent-free survivalArm AOverall survivalComplete remissionDouble-blindArm CCases of acute myeloid leukemiaAcute myeloid leukemia blastsAcute myeloid leukemia casesFLT3-ITD-negativeHigh-dose cytarabineFLT3 gene mutationsType II FLT3 inhibitorsPlacebo-controlled trialProlonged overall survivalAllele frequency <5%Leukemic cell survivalArm BStandard chemotherapyEligible ptsInduction/consolidation chemotherapyPrimary endpointSecondary endpoints
2023
Safety of ovarian cryopreservation and transplantation in patients with acute leukemia: a case series
Sönmezer M, Şükür Y, Saçıntı K, Özkavukçu S, Kankaya D, Atabekoğlu C, Cengiz Seval G, Oktay K. Safety of ovarian cryopreservation and transplantation in patients with acute leukemia: a case series. American Journal Of Obstetrics And Gynecology 2023, 230: 79.e1-79.e10. PMID: 37666382, DOI: 10.1016/j.ajog.2023.08.032.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationAllogeneic hematopoietic stem cell transplantationOvarian tissue cryopreservationOvarian tissue transplantationStem cell transplantationSerum antimüllerian hormoneCell transplantationTissue cryopreservationAcute leukemiaTissue transplantationSerum AMHAntimüllerian hormoneCase seriesAllogenic hematopoietic stem cell transplantationInduction/consolidation chemotherapyFollicle-stimulating hormone levelsFertility preservation optionsAntral follicle countAcute leukemia survivorsAcute lymphoblastic leukemiaAcute myeloid leukemiaPrimary ovarian insufficiencyBerlin-FrankfurtBFM 95Consolidation chemotherapy
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