2018
Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats
Gao HT, Xu R, Cao WX, Di QN, Li RX, Lu L, Xu Q, Yu SQ. Combined effects of simultaneous exposure to six phthalates and emulsifier glycerol monosterate on male reproductive system in rats. Toxicology And Applied Pharmacology 2018, 341: 87-97. PMID: 29366639, DOI: 10.1016/j.taap.2018.01.013.Peer-Reviewed Original ResearchConceptsRat reproductive systemFood emulsifier glycerin monostearateReproductive systemMale rat reproductive systemSteroidogenic proteinsMale reproductive toxicityMale reproductive systemTime-dependent mannerSerum testosteroneAndrogen metabolismMale ratsReproductive toxicityMorphological damageUbiquitous phthalate estersMetabonomic analysisDaily dietSimultaneous exposureToxic effectsRatsGlycerin monostearateMixPToxicityHormone biosynthesisExposureGavage
2008
Inherited Variation in the Androgen Pathway Is Associated With the Efficacy of Androgen-Deprivation Therapy in Men With Prostate Cancer
Ross R, Oh W, Xie W, Pomerantz M, Nakabayashi M, Sartor O, Taplin M, Regan M, Kantoff P, Freedman M. Inherited Variation in the Androgen Pathway Is Associated With the Efficacy of Androgen-Deprivation Therapy in Men With Prostate Cancer. Journal Of Clinical Oncology 2008, 26: 842-847. PMID: 18281655, DOI: 10.1200/jco.2007.13.6804.Peer-Reviewed Original ResearchConceptsEfficacy of androgen deprivation therapyAndrogen deprivation therapyTime to progressionProstate cancerAdvanced prostate cancers treated with androgen deprivation therapyProstate cancer treated with androgen deprivation therapyResponse to ADTAssociated with time to progressionImproved time to progressionInfluence of inherited variationAdvanced prostate cancerEffective systemic therapyResponse to therapyAndrogen metabolic pathwaysGermline genetic variationDNA polymorphismsAndrogen deprivationAndrogen axisGenetic variationSystemic therapyGenotype patientsAndrogen pathwayClinical benefitAndrogen metabolismInherited variation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply