5 Aurora kinase inhibition synergizes with Fanconi anemia pathway defects to limit tumorigenesis
Doorodian P, Nagarajan A, Burtness B, Kupfer G, Stahl E. 5 Aurora kinase inhibition synergizes with Fanconi anemia pathway defects to limit tumorigenesis. Journal Of Clinical And Translational Science 2025, 9: 1-2. PMCID: PMC12050673, DOI: 10.1017/cts.2024.697.Peer-Reviewed Original ResearchFA-D2MRNA expressionAurora kinasesPatient survivalHPV-negative head and neck cancersFanconi anemiaHomologous recombination deficiency scoresSynthetic lethal genesHead and neck cancerAssociated with poor patient survivalTumor mRNA expressionPan-cancer datasetKnockdown of AURKADNA damage repairPoor patient survivalAurora kinase inhibitionTCGA pan-cancer datasetsIncreased ~5-foldMutant cellsAurora kinase inhibitorsFA mutationsCancer Genome AtlasTumor gradeDNA repair proficiencySiRNA-based
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