Chemical, Biochemical, and Structural Similarities and Differences of Dermatological cAMP Phosphodiesterase-IV Inhibitors
Wang J, Ho M, Bunick C. Chemical, Biochemical, and Structural Similarities and Differences of Dermatological cAMP Phosphodiesterase-IV Inhibitors. Journal Of Investigative Dermatology 2024, 145: 1471-1488.e1. PMID: 39608668, PMCID: PMC12103293, DOI: 10.1016/j.jid.2024.10.597.Peer-Reviewed Original ResearchTreatment of psoriasisTopical treatmentAtopic dermatitisTopical treatment of atopic dermatitisIncreased cellular cAMP concentrationOral treatment of psoriasisPDE4 inhibitorsTopical treatment of psoriasisTreatment of atopic dermatitisCellular cAMP concentrationAnti-inflammatory effectsPhosphodiesterase-IV inhibitorImmune cellsOral treatmentPDE4 inhibitionSeborrheic dermatitisInflammatory responseCAMP concentrationAdenosine monophosphateRoflumilastDuration of cAMP signalingPDE4CAMP SignalingDermatitisApremilast
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