2022
Intramuscular (IM) INO-5401 + INO-9012 with electroporation (EP) in combination with cemiplimab (REGN2810) in newly diagnosed glioblastoma.
Reardon D, Brem S, Desai A, Bagley S, Kurz S, De La Fuente M, Nagpal S, Welch M, Hormigo A, Forsyth P, Mandel J, Khagi S, Aiken R, Walbert T, Lieberman F, Portnow J, Battiste J, Gillespie E, Lowy I, Skolnik J. Intramuscular (IM) INO-5401 + INO-9012 with electroporation (EP) in combination with cemiplimab (REGN2810) in newly diagnosed glioblastoma. Journal Of Clinical Oncology 2022, 40: 2004-2004. DOI: 10.1200/jco.2022.40.16_suppl.2004.Peer-Reviewed Original ResearchPre-treatment tissueCohort AT cellsLytic potentialAntigen-specific T cellsImmune responsePost-treatment tumor tissuesFlow cytometryMedian OS durationMGMT-unmethylated patientsPD-1 inhibitorsDiagnosed GBM patientsT cell infiltrationAdverse event profileImmune-related markersImmune cell markersRobust immune responseCellular immune responsesWilcoxon rank sum testImmune response suppressionGene expressionPresence of perforinGene expression signaturesRank sum testMedian OS
2021
Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition
Yuan S, Balaji S, Lomakin IB, Xiong Y. Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition. Frontiers In Microbiology 2021, 12: 752214. PMID: 34659188, PMCID: PMC8512706, DOI: 10.3389/fmicb.2021.752214.Peer-Reviewed Original ResearchImmune responseImmune response suppressionSARS-CoV-2Nonstructural protein 1Host protein expressionMillions of deathsVaccine developmentProtein expressionProtein 1Causative agentViral RNAExpression inhibitionExpression levelsCOVID-19 pandemicMultiple mechanismsPublic healthViral proteinsGene expression levelsResponse suppressionCoronavirusHost cellsInhibitionCurrent dataGlobal gene expression levelsProtein synthesis
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