Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression
Carrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression. Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.Peer-Reviewed Original ResearchConceptsGene expressionDNA methylationLymphoblastoid cell linesRegulatory mechanismsDNA hypomethylationParental linesHybrid linesSomatic cell hybridsRestriction enzyme Hpa IIHpa II digestionMsp I siteDifferent regulatory mechanismsCell hybridsGenomic probesGene inductionUnexpressed genesComplete demethylationHpa IIGenesDR genesMethylationT-LCLCell linesI siteHypomethylationLocalization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus.
de Martinville B, Kunkel L, Bruns G, Morlé F, Koenig M, Mandel J, Horwich A, Latt S, Gusella J, Housman D. Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus. American Journal Of Human Genetics 1985, 37: 235-49. PMID: 2984924, PMCID: PMC1684559.Peer-Reviewed Original ResearchConceptsX chromosomeHuman X chromosome short armSomatic cell hybrid linesMolecular markersShort armX chromosome short armHuman X chromosomeChromosome short armDNA sequence mapGene dosage studiesOrnithine transcarbamylase geneAbnormal X chromosomeDNA sequencesDNA fragmentsHybrid linesChromosomesSequence mapsMuscular dystrophyStructural rearrangementsHuman lymphoblastsBand Xp21Duchenne muscular dystrophyGenesLociXp21
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