2017
A cell-penetrating antibody inhibits human RAD51 via direct binding
Turchick A, Hegan DC, Jensen RB, Glazer PM. A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic Acids Research 2017, 45: 11782-11799. PMID: 29036688, PMCID: PMC5714174, DOI: 10.1093/nar/gkx871.Peer-Reviewed Original ResearchConceptsHomology-directed repairMolecular basisDirect bindingSynthetic lethal killingPre-clinical developmentBRCA2-deficient cancer cellsCell-penetrating antibodiesAnti-cancer agentsLupus autoantibodiesHuman Rad51DNA repairDNA bindingRAD51N-terminusCancer cellsSilico molecular modelingFunction mutationsCancer therapySpecific inhibitorDNANovel inhibitorsAttractive targetComplementarity-determining regionsMolecular modelingCell penetration
1999
Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein
Gupta R, Folta-Stogniew E, O'Malley S, Takahashi M, Radding C. Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein. Molecular Cell 1999, 4: 705-714. PMID: 10619018, DOI: 10.1016/s1097-2765(00)80381-0.Peer-Reviewed Original ResearchConceptsRecognition of homologyBase pairsRad51 recombination proteinT base pairsRecombination proteinsHuman Rad51Genetic exchangeFluorescence resonance energy transferUbiquitous familyMechanism of recognitionDNA repairStrand exchangeDNA homologyBase substitutionsHomologyResonance energy transferDuplex DNAHelix destabilizationCritical roleBase mismatchesProteinSingle strandsRAD51Rapid exchangeKinetic analysis
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