Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
Cale J, Ham K, Li D, McIntosh C, Watts G, Wilton S, Aung-Htut M. Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations. Scientific Reports 2023, 13: 19725. PMID: 37957262, PMCID: PMC10643364, DOI: 10.1038/s41598-023-47005-y.Peer-Reviewed Original ResearchConceptsProtein isoformsAntisense oligomersModulate RNA processingLDL receptorInduce alternative splicingLevels of LDL receptorPhysiologically relevant concentrationsHuh-7 cellsLow-density lipoprotein (LDL) receptorProtein domainsRNA processingAlternative splicingExon 2Exon 8Target exonsHinge regionExonHuh-7LDL receptor activityIsoformsPhysiologically relevant levelsLDL uptakeSplicingIsoform expressionProtein overexpression
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