2015
Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy
De Silva Feelixge H, Stone D, Pietz H, Roychoudhury P, Greninger A, Schiffer J, Aubert M, Jerome K. Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy. Antiviral Research 2015, 126: 90-98. PMID: 26718067, PMCID: PMC4724322, DOI: 10.1016/j.antiviral.2015.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsBase SequenceCell LineDNA, ViralDrug Resistance, ViralEndonucleasesExodeoxyribonucleasesGene Products, polHEK293 CellsHIV InfectionsHIV ProteaseHIV Reverse TranscriptaseHIV-1HumansMolecular Sequence DataMutationPhosphoproteinsReverse Transcriptase InhibitorsTransduction, GeneticVirus ReplicationZinc FingersConceptsAntiviral therapyTreatment resistancePrimary CD4(+) T cellsCD4(+) T cellsEmergence of treatment resistanceViral infectionChronic viral infectionsReverse transcriptasePersistent viral infectionEmergence of resistanceDomain of RTInhibit viral replicationSusceptible to treatmentInfectious HIVT cellsInfectious mutant virusTherapyViral replicationMutant virusRT inhibitorsInfectious virusZinc finger nucleasesInfectionVirusHIV protease
2001
Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug
KRYNETSKAIA N, FENG J, KRYNETSKI E, GARCIA J, PANETTA J, ANDERSON K, EVANS W. Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug. The FASEB Journal 2001, 15: 1902-1908. PMID: 11532970, DOI: 10.1096/fj.01-0124com.Peer-Reviewed Original ResearchConceptsAnti-retroviral agentsHIV replicationHIV-1 reverse transcriptaseReverse transcriptaseTreatment of HIVHuman lymphocyte culturesDifferent medicationsHost lymphocytesAdditive cytotoxicityHIV-1Old drugsLymphocyte culturesActive metaboliteHuman lymphocytesMinimal toxicityLymphocytesThioguanineSubstantial inhibitionTreatmentInhibitionHIV proteaseEarly stagesMedicationsHIVPatients
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