Effect of Tumor Heterogeneity on the Assessment of Ki67 Labeling Index in Well-differentiated Neuroendocrine Tumors Metastatic to the Liver
Yang Z, Tang L, Klimstra D. Effect of Tumor Heterogeneity on the Assessment of Ki67 Labeling Index in Well-differentiated Neuroendocrine Tumors Metastatic to the Liver. The American Journal Of Surgical Pathology 2011, 35: 853-860. PMID: 21566513, DOI: 10.1097/pas.0b013e31821a0696.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBiopsyCarcinoma, NeuroendocrineFemaleHepatectomyHumansImage Processing, Computer-AssistedKaplan-Meier EstimateKi-67 AntigenLiver NeoplasmsMaleMiddle AgedNew YorkPrognosisReproducibility of ResultsRetrospective StudiesSurvival RateTissue Array AnalysisConceptsKi67 labeling indexWell-differentiated neuroendocrine tumorsMetastatic neuroendocrine tumorsNeuroendocrine tumorsKi67 indexKi67 gradeLabeling indexOverall survivalCore biopsyPatient survivalTumor heterogeneityIntratumoral heterogeneityStatistically significant prognostic valueSurgically resected liver metastasesVirtual biopsySignificant prognostic valueKaplan-Meier survival analysisProgression-free survivalWhole slidesEffect of tumor heterogeneityDisease-free survivalGastroenteropancreatic neuroendocrine tumorsNeedle core biopsyChoice of treatmentHigher proliferative rate
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