2021
HCV Viral Load Greater Than 1000 IU/ml at Time of Virologic Failure in Direct-Acting Antiviral-Treated Patients
Morgan JR, Savinkina A, Pires dos Santos AG, Xue Z, Shilton S, Linas B. HCV Viral Load Greater Than 1000 IU/ml at Time of Virologic Failure in Direct-Acting Antiviral-Treated Patients. Advances In Therapy 2021, 38: 1690-1700. PMID: 33590445, PMCID: PMC7932931, DOI: 10.1007/s12325-021-01647-4.Peer-Reviewed Original ResearchConceptsMean HCV RNA levelHCV RNA levelsVirologic failureIU/HCV RNARNA levelsPost-treatment week 4Hepatitis C cureMean HCV RNATreatment virologic failureLevel of viremiaDirect acting antiviralsHCV viral loadTime of relapseResource-limited settingsTreatment failureViral loadElimination targetsClinical trialsWeek 4PatientsCare testOverall populationCare assaysLarger study
2017
Effect of Sofosbuvir-Based Hepatitis C Virus Therapy on Kidney Function in Patients with CKD
Sise ME, Backman E, Ortiz GA, Hundemer GL, Ufere NN, Chute DF, Brancale J, Xu D, Wisocky J, Lin MV, Kim AY, Thadhani R, Chung RT. Effect of Sofosbuvir-Based Hepatitis C Virus Therapy on Kidney Function in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 12: 1615-1623. PMID: 28882857, PMCID: PMC5628711, DOI: 10.2215/cjn.02510317.Peer-Reviewed Original ResearchConceptsSustained virologic responseAdverse eventsVirologic responseAntiviral therapyOverall sustained virologic responsePrior solid organ transplantHepatitis C virus (HCV) therapyEffect of sofosbuvirEfficacy of sofosbuvirHepatitis C cureRetrospective observational cohortC virus infectionSerious adverse eventsSolid organ transplantsC virus therapyCohort of patientsLarge health care systemPost-treatment followHepatitis C virusHealth care systemBaseline eGFRTreatment discontinuationObservational cohortKidney functionRegression models
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