H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability
Yuan W, Huang Y, LeBlanc C, Poulet A, De Luna Vitorino F, Valsakumar D, Dean R, Garcia B, van Wolfswinkel J, Voigt P, Jacob Y. H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability. Nature Communications 2025, 16: 3547. PMID: 40229276, PMCID: PMC11997104, DOI: 10.1038/s41467-025-58892-2.Peer-Reviewed Original ResearchConceptsGenomic instabilityChromatin-based mechanismsHistone mark H3K27me3DNA damageH3K27MChromatin maturityGenome integrityNascent chromatinCell identityHistone H3Transcriptional programsH3.1 variantsGenomic alterationsDNAGenomeHistoneH3K27M expressionTumors of patientsEctopic activityATXR5ATXR6ExpressionCellsChromatin
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