2023
Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions
Chen H, Rosen C, González-Hernández J, Song D, Potempa J, Ring A, Palm N. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell 2023, 186: 3095-3110.e19. PMID: 37321219, PMCID: PMC10330796, DOI: 10.1016/j.cell.2023.05.024.Peer-Reviewed Original Research
2022
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude K, Suomivuori C, Panova O, Waghray D, Kato H, Velasco A, Dror R, Skiniotis G, Kobilka B, Garcia K. Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science Advances 2022, 8: eabl5442. PMID: 35061538, PMCID: PMC8782444, DOI: 10.1126/sciadv.abl5442.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsCryo-electron microscopy structureG-proteinSubversion of host immunityHuman cytomegalovirusLigand-binding pocketTransition stateStructural snapshotsCurved membranesDocking modeTrapped intermediateGPCR interactionsViral pathogenesisGPCR-G protein couplingFunctional implicationsHost immunityGi signalingUS27Protein coupling
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