2020
HLA tapasin independence: broader peptide repertoire and HIV control
Bashirova A, Viard M, Naranbhai V, Grifoni A, Garcia-Beltran W, Akdag M, Yuki Y, Gao X, O’hUigin C, Raghavan M, Wolinsky S, Bream J, Duggal P, Martinson J, Michael N, Kirk G, Buchbinder S, Haas D, Goedert J, Deeks S, Fellay J, Walker B, Goulder P, Cresswell P, Elliott T, Sette A, Carlson J, Carrington M. HLA tapasin independence: broader peptide repertoire and HIV control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 28232-28238. PMID: 33097667, PMCID: PMC7668082, DOI: 10.1073/pnas.2013554117.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenCytotoxic T cell responsesImmune responseHIV-1 proteomeT cell responsesTapasin dependenceEx vivo examinationHLA-ILeukocyte antigenViral loadInfected subjectsHIV-1Peptide presentationPeptide repertoireAllotypesIndependent progressionAbsence of tapasinPeptide loading complexTapasinAfrican AmericansPeptideAntigenResponse
1998
HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading
Peh C, Burrows S, Barnden M, Khanna R, Cresswell P, Moss D, McCluskey J. HLA-B27–Restricted Antigen Presentation in the Absence of Tapasin Reveals Polymorphism in Mechanisms of HLA Class I Peptide Loading. Immunity 1998, 8: 531-542. PMID: 9620674, DOI: 10.1016/s1074-7613(00)80558-0.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsAntigen PresentationAntiportersATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette Transportersbeta 2-MicroglobulinCells, CulturedDisease SusceptibilityHLA-B AntigensHLA-B27 AntigenHLA-B44 AntigenHumansImmunoglobulinsMembrane Transport ProteinsMicePolymorphism, GeneticProtein BindingSurface PropertiesTransfection
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