2022
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman G, Mani A. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal Of Clinical Investigation 2022, 132: e153724. PMID: 34855620, PMCID: PMC8803348, DOI: 10.1172/jci153724.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisNonalcoholic steatohepatitisInsulin resistanceHepatic lipogenesisElevated de novo lipogenesisNonalcoholic fatty liver diseaseFatty liver diseaseLiver of patientsHepatic glycogen storageHigh-sucrose dietHepatic insulin resistanceFatty acid uptakeMetabolic syndromeLiver diseaseHepatic steatosisTriacylglycerol secretionNovo lipogenesisHepatic insulinTherapeutic targetImpaired activationAcid uptakeGlycogen storageMouse liverLiverLipogenesis
2015
Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions
Vyas M, Zhang X, Morrow JS, Jain D, Salem RR, West AB. Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions. Pathology - Research And Practice 2015, 212: 59-62. PMID: 26627264, DOI: 10.1016/j.prp.2015.11.006.Peer-Reviewed Original Research
2002
Early postexercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement
Ivy J, Goforth H, Damon B, McCauley T, Parsons E, Price T. Early postexercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement. Journal Of Applied Physiology 2002, 93: 1337-1344. PMID: 12235033, DOI: 10.1152/japplphysiol.00394.2002.Peer-Reviewed Original ResearchConceptsCarbohydrate-protein supplementCHO-PRO treatmentMuscle glycogen storesMuscle glycogenGlycogen storesEqual carbohydrate contentPlasma insulin responseMin of recoveryMuscle glycogen recoveryCHO-PROPlasma glucoseInsulin responseH postexerciseCHO supplementGlycogen recoveryVastus lateralisCarbohydrate supplementLCHOGlycogen storageSignificant differencesTreatmentIntense cyclingExerciseSupplementsGlycogen
2001
Regulation of Hepatic Glucose Uptake
Taylor R, Shulman G. Regulation of Hepatic Glucose Uptake. 2001, 787-802. DOI: 10.1002/cphy.cp070226.Peer-Reviewed Original ResearchHepatic glucose productionHepatic glucose uptakeGlucose productionGlucose uptakeHepatic glycogen storageLiver glycogen storesHepatic glycogen contentGlycogen storage diseaseNormal diurnal fluctuationsPortal signalPostprandial statePostabsorptive stateGlycogen storesGlycogen contentGlucagon regulationGlycogen storageHomeostatic mechanismsStorage diseaseGlycogen synthesisEarly adaptationMetabolismGlucose carbonCirrhosis
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