Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons
Espinosa‐Garcia C, Srivastava U, Kumar P, Tobin B, Xiao H, Cheng L, Bagchi P, Duong D, Seyfried N, Faundez V, Wood L, Rangaraju S. Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons. Alzheimer's & Dementia 2024, 20: e090723. PMCID: PMC11710382, DOI: 10.1002/alz.090723.Peer-Reviewed Original ResearchProteomic effectsLabel-free quantitative mass spectrometryCytoskeleton-related proteinsAlzheimer's disease pathogenesisProteome in vivoIncreased aerobic respirationCellular signaling pathwaysQuantitative mass spectrometryDisease pathogenesisCytoskeleton organizationSubcellular compartmentsOxidoreductase activitySynaptic vesiclesProteomic approachAerobic respirationBiological pathwaysNeuroinflammatory stressSignaling pathwaySynapse-related proteinsMAPK signalingMetabolic processesDifferential centrifugationMitochondriaSomatodendritic compartmentRegulating activity
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