Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target
Chen E, Chuang LS, Giri M, Villaverde N, Hsu NY, Sabic K, Joshowitz S, Gettler K, Nayar S, Chai Z, Alter IL, Chasteau CC, Korie UM, Dzedzik S, Thin TH, Jain A, Moscati A, Bongers G, Duerr RH, Silverberg MS, Brant SR, Rioux JD, Peter I, Schumm LP, Haritunians T, McGovern DP, Itan Y, Cho JH. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology 2021, 160: 1709-1724. PMID: 33421512, PMCID: PMC8494017, DOI: 10.1053/j.gastro.2020.12.076.Peer-Reviewed Original ResearchMeSH KeywordsAdrenomedullinAnimalsbeta-Arrestin 2Case-Control StudiesCell DegranulationCHO CellsColitis, UlcerativeColonCricetulusExtracellular Signal-Regulated MAP KinasesGenetic VariationHumansInositol PhosphatesLigandsMast CellsNerve Tissue ProteinsPhosphorylationReceptors, G-Protein-CoupledReceptors, NeuropeptideConceptsExtracellular signal-regulated kinaseSignal-regulated kinaseRNA sequencingArrestin recruitmentChinese hamster ovarySingle-cell RNA sequencingNew therapeutic targetsBulk RNA sequencingMast cell gene expressionCell gene expressionHuman ulcerative colitisKey upstream regulatorUlcerative colitisMast cell activationIP-1 accumulationSingle nucleotide polymorphismsTherapeutic targetCell activationCell-specific mediatorsUpstream regulatorGene expressionGenotype-dependent effectsG proteinsMast cellsIgE-independent mast cell activation
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