2023
KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†
Walters B, Rainsford S, Heuer R, Dias N, Huang X, de Rooij D, Lesch B. KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†. Biology Of Reproduction 2023, 110: 391-407. PMID: 37861693, PMCID: PMC11484508, DOI: 10.1093/biolre/ioad141.Peer-Reviewed Original ResearchMale germ lineGerm lineGenome-wide epigenetic profilingGene regulatory statesHeritable epigenetic statesHundreds of genesLoss of KDM6AEarly meiotic prophaseSpermatogenic cellsSpermatogenic gene expressionKDM6A/UTXPaternal germ lineDemethylation of H3K27me3H3K27me3 peaksH3K27me3 domainsMisregulated genesEpigenetic stateChromatin organizationRepressive modificationsTranscriptional activatorMammalian spermatogenesisChromatin undergoesLysine demethylase 6AEpigenetic profilingGene activation
2020
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
Ohkura N, Yasumizu Y, Kitagawa Y, Tanaka A, Nakamura Y, Motooka D, Nakamura S, Okada Y, Sakaguchi S. Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases. Immunity 2020, 52: 1119-1132.e4. PMID: 32362325, DOI: 10.1016/j.immuni.2020.04.006.Peer-Reviewed Original ResearchMeSH KeywordsAutoimmune DiseasesBiomarkersCell DifferentiationComputational BiologyCpG IslandsDNA MethylationEpigenesis, GeneticEpigenomicsGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationHumansImmunophenotypingPolymorphism, Single NucleotideT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryTranscriptomeConceptsCommon autoimmune diseasesSingle-nucleotide polymorphismsSusceptibility to common autoimmune diseasesCell-specific gene transcriptionGenome-wide epigenetic profilingAssociated with common autoimmune diseasesAssociated with transcriptionPolygenic autoimmune diseasesTreg cellsDemethylated regionCpG hypomethylationSuper-enhancersAutoimmune diseasesDeterminants of susceptibilityEpigenetic modificationsEpigenetic profilesGene transcriptionEpigenetic changesTreg-cell-specific demethylated regionNaive Treg cellsNatural Treg cellsRegional variantsTranscriptionActive stateCells
2018
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1–Positive Lung Adenocarcinomas
Miyashita N, Horie M, Suzuki H, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T. An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1–Positive Lung Adenocarcinomas. Journal Of Thoracic Oncology 2018, 13: 1676-1691. PMID: 30121393, DOI: 10.1016/j.jtho.2018.07.096.Peer-Reviewed Original ResearchConceptsAchaete-scute family bHLH transcription factor 1Transcriptome profilingGenome-wide epigenetic profilingRecent transcriptome profilingGenome-wide methylation analysisFamily bHLH transcription factor 1Cell cycle controlMaster transcriptional regulatorGene expression profilingGlobal DNA hypomethylationLung adenocarcinomaEpigenome featuresTranscription factor 1Transcriptional regulatorsTranscriptional programsCancer Genome AtlasEpigenetic profilingLung adenocarcinoma cellsMolecular featuresExpression profilingCycle controlDNA hypomethylationIntegrative analysisMethylation analysisCell death ligand-1 (PD-L1) protein expression
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