Transcriptional adaptation after deletion of Cdc42 in primary T cells
Rochussen A, Y. C, Griffiths G. Transcriptional adaptation after deletion of Cdc42 in primary T cells. Journal Of Cell Science 2025, 138: jcs263826. PMID: 40613419, PMCID: PMC12377712, DOI: 10.1242/jcs.263826.Peer-Reviewed Original ResearchTranscriptional adaptationRho family GTPasesPrimary T cellsNonsense-mediated decay mechanismWild-type cellsInhibition of Cdc42Deletion of Cdc42Study protein functionCRISPR-mediated deletionFamily GTPasesRho GTPasesEssential genesCytotoxic T lymphocytesCytoskeletal regulationGenetic compensationPolarised secretionCdc42 deletionProtein functionCdc42 proteinCdc42Cell polarityPromoter regionTranscriptional changesGene deletionChemical inhibition
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