Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma
Mitchell O, Gilliam K, del Gaudio D, McNeely K, Smith S, Acevedo M, Gaduraju M, Hodge R, Ramsland A, Segal J, Das S, Hathaway F, Bryan D, Tawde S, Galasinski S, Wang P, Tjota M, Husain A, Armato S, Donington J, Ferguson M, Turaga K, Churpek J, Kindler H, Drazer M. Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma. JAMA Network Open 2023, 6: e2327351. PMID: 37556141, PMCID: PMC10413174, DOI: 10.1001/jamanetworkopen.2023.27351.Peer-Reviewed Original ResearchConceptsP/LP germline variantsGermline P/LP variantsP/LP variantsGermline variantsNext-generation sequencingGermline testingGenomic profiles of patientsHereditary cancer syndrome diagnosisTumor-only sequencingProportion of patientsPositive predictive valueProfile of patientsUniversal germline testingCase seriesFollow-upGenomic profilingMesotheliomaSyndrome diagnosisPatientsGermline originPredictive valueP/LPGermlineNon-Hispanic whitesClinical approach
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply