2012
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, Baylin SB, Herman JG, Ahuja N. Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012, 7: 701-709. PMID: 22647880, DOI: 10.4161/epi.20445.Peer-Reviewed Original ResearchConceptsPoor overall survivalBreast cancerOverall survivalPrognosis predictionEffective biomarkersClinical prognostic variablesPrimary breast cancerDetection of BCFrequent methylated genesStrongest single markersSignificant prognosticatorBC patientsValidation cohortPrognostic variablesPrognostic signatureEarly detectionCancerBiomarkersPromoter hypermethylationMethylation changesTumor heterogeneityPrognosisSingle markerGene expression approachSurvival
1992
The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase.
Zahler R, Brines M, Kashgarian M, Benz E, Gilmore-Hebert M. The cardiac conduction system in the rat expresses the alpha 2 and alpha 3 isoforms of the Na+,K(+)-ATPase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 99-103. PMID: 1309618, PMCID: PMC48183, DOI: 10.1073/pnas.89.1.99.Peer-Reviewed Original ResearchConceptsAlpha 3 isoformAlpha 2Gene expression approachAlpha 1 isoformIsoform genesSpecific hybridization signalAlpha subunitSpecific expressionMembrane channelsSpecific membrane channelsHybridization signalsIsoformsWorking myocytesCardiac conduction systemExcitable tissuesSodium pumpGenesSubunitsATPaseTissueExpressionStrands
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