Effect of Methylene Blue on White Matter Injury after Ischemic Stroke
Cheng Q, Chen X, Ma J, Jiang X, Chen J, Zhang M, Wu Y, Zhang W, Chen C. Effect of Methylene Blue on White Matter Injury after Ischemic Stroke. Oxidative Medicine And Cellular Longevity 2021, 2021: 6632411. PMID: 33603949, PMCID: PMC7872771, DOI: 10.1155/2021/6632411.Peer-Reviewed Original ResearchConceptsWhite matter injuryMiddle cerebral artery occlusionCerebral artery occlusionInfarct volumeIschemic strokeArtery occlusionBehavioral deficitsFDA-grandfathered drugWhite matter protectionBrain white matter injuryAdministration of MBGarcia neurological scoresTherapeutic time windowEffect of methylene bluePhotothrombotic middle cerebral artery occlusionPotential therapeutic effectsFoot-fault testNeurological deficitsMyelin basic proteinIntraperitoneal administrationNeurological scoreAnimal modelsTherapeutic effectMB administrationTTC staining
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