2014
Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders
Kos MZ, Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen X, Deng H, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 294-302. PMID: 24692236, PMCID: PMC4172449, DOI: 10.1002/ajmg.b.32231.Peer-Reviewed Original ResearchConceptsSan Antonio Family StudyGenome-wide SNPsSignificant SNP associationsSignificant pleiotropic effectsCompelling candidate genesStrong genetic correlationPotential risk locusNovel QTLChromosome 6p22.3Significant QTLGene actionChromosome regionsChromosome 4Heritable phenotypesCandidate genesRisk lociLinkage signalChromosome 6p22QTLSNP associationsLinkage regionGenetic correlationsSusceptibility genesPleiotropic effectsGenes
2013
Neuron-Specific Feeding RNAi in C. elegans and Its Use in a Screen for Essential Genes Required for GABA Neuron Function
Firnhaber C, Hammarlund M. Neuron-Specific Feeding RNAi in C. elegans and Its Use in a Screen for Essential Genes Required for GABA Neuron Function. PLOS Genetics 2013, 9: e1003921. PMID: 24244189, PMCID: PMC3820814, DOI: 10.1371/journal.pgen.1003921.Peer-Reviewed Original ResearchConceptsCell-specific knockdownEssential genesFeeding RNAiC. elegansGenetic requirementsNeuronal functionForward genetic screenGABA neuron functionGene function resultsForward screenGenetic screenRNAi resultsRNAi strainsChromosome IRNAi clonesGlutamate-releasing neuronsGene actionGene knockdownMature organismRNAiGenesKnockdownNeuron functionElegansPleiotropy
2008
Two GATA Transcription Factors Are Downstream Effectors of Floral Homeotic Gene Action in Arabidopsis
Mara CD, Irish VF. Two GATA Transcription Factors Are Downstream Effectors of Floral Homeotic Gene Action in Arabidopsis. Plant Physiology 2008, 147: 707-718. PMID: 18417639, PMCID: PMC2409029, DOI: 10.1104/pp.107.115634.Peer-Reviewed Original ResearchConceptsTranscription factorsChlorophyll biosynthesisMADS-box transcription factorsSpecification of petalGATA transcription factor familyNutrient-responsive genesFloral organ identityComplex regulatory interplayDirect regulatory interactionsGATA transcription factorsTranscription factor familyExpression of suitesStamen identityOrgan identityTranscriptional cascadeAPETALA3Regulatory interplayChromatin immunoprecipitationCombinatorial actionFloral organogenesisResponsive genesRedundant rolesRegulatory interactionsGene actionPromoter sequences
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