Assessment of ctDNA somatic homologous recombination deficiency (HRD) in triple-negative breast cancer (TNBC) from SWOG S1416 trial.
Stecklein S, Barlow W, Tsai J, Yablonovitch A, Rodler E, Kuhn P, Hicks J, Pathak H, Hayes D, Rae J, Hortobagyi G, Thompson A, Godwin A, Pusztai L, Sharma P. Assessment of ctDNA somatic homologous recombination deficiency (HRD) in triple-negative breast cancer (TNBC) from SWOG S1416 trial. Journal Of Clinical Oncology 2025, 43: 1012-1012. DOI: 10.1200/jco.2025.43.16_suppl.1012.Peer-Reviewed Original ResearchTriple-negative breast cancerHomologous recombination deficiencyProgression-free survivalMetastatic TNBCWildtype patientsMetastatic triple-negative breast cancerHomologous recombination deficiency phenotypePre-treatment blood samplesDetect somatic alterationsPredictive of benefitDNA-damaging chemotherapyEvaluated pre-treatmentGBRCA mutationRecombination deficiencyPARP inhibitorsSomatic alterationsGBRCABRCABreast cancerGene panelPathway alterationsVeliparibHomologous recombination repairBiomarker panelAssociated with benefits
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