2013
Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner
Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner. Journal Of Allergy And Clinical Immunology 2013, 133: 872-879.e7. PMID: 24373351, PMCID: PMC3961577, DOI: 10.1016/j.jaci.2013.10.054.Peer-Reviewed Original ResearchConceptsT cell responsesGrass pollen allergyAllergen-specific immunotherapyPollen allergyAllergen-specific T-cell responsesAllergen-specific Th2 cellsAllergen-specific CD4Epitope-dependent mannerEpitope hierarchyTr1 responsesTr1 cellsNonatopic subjectsAllergic inflammationPeripheral toleranceAllergic subjectsVaccine strategiesTh2 cellsAntigen stimulationDistinct functional profilesT cellsEpitope levelAllergyEpitope changesImmunotherapyCell deletion
2011
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. Journal Of Allergy And Clinical Immunology 2011, 129: 544-551.e7. PMID: 21975176, PMCID: PMC3268867, DOI: 10.1016/j.jaci.2011.08.034.Peer-Reviewed Original ResearchConceptsNonallergic subjectsT cellsPollen allergyPeptide-MHC class II tetramersAllergen-specific T cellsChemoattractant receptor-homologous moleculeAllergen-specific CD4Natural pollen exposureAllergen-specific immunotherapyClass II tetramersProtective immune responseT cell outcomesIL-10 inductionLymphocyte expressionSpecific immunotherapyIL-10Allergic subjectsAllergy vaccinationCytokine productionImmune responseDifferentiation stageSeasonal allergiesPollen exposureAllergyProtective response
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