The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression
Ahronian L, Driscoll D, Klimstra D, Lewis B. The p53R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression. PLOS ONE 2015, 10: e0123816. PMID: 25885474, PMCID: PMC4401698, DOI: 10.1371/journal.pone.0123816.Peer-Reviewed Original ResearchConceptsAnchorage-independent growthMutant-expressing cellsHCC cell linesP53 mutantsKnockdown of mutant p53Cell linesP53-null counterpartsCell migrationFrequency of p53 mutationsP53-null cellsP73 target genesTA isoforms of p63Analysis of cell linesP53 family membersP53 tumor suppressor geneTumor-free survivalHCC mouse modelHCC cellsIncreased tumor incidenceShRNA-mediated knockdownTumor suppressor geneGain-of-function mutationsDecreased cell migrationHepatocellular carcinoma developmentIsoforms of p63
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