2024
Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator
Mandino F, Shen X, Desrosiers-Grégoire G, O’Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty M, Strittmatter S, Lake E. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator. Molecular Psychiatry 2024, 30: 1730-1745. PMID: 39424929, PMCID: PMC12015114, DOI: 10.1038/s41380-024-02779-z.Peer-Reviewed Original ResearchFunctional connectivity deficitsConnectivity deficitsFunctional connectivityBrain connectivityAllosteric modulators of mGluR5Alzheimer's diseaseDefault-mode networkModulation of mGluR5Loss of functional connectivityResting-state fMRIApplication of fMRIWild-type controlsAged AD miceMouse model of Alzheimer's diseaseAD-related changesAD miceModel of Alzheimer's diseaseAssociated with synaptic damageMGluR5 modulationMonths of ageFMRI measurementsAmyloid accumulationDecreased connectivityBrain networksSilent allosteric modulators
2010
Quantification of CMRO2 without hypercapnia using simultaneous near-infrared spectroscopy and fMRI measurements
Tak S, Jang J, Lee K, Ye JC. Quantification of CMRO2 without hypercapnia using simultaneous near-infrared spectroscopy and fMRI measurements. Physics In Medicine And Biology 2010, 55: 3249-3269. PMID: 20479515, DOI: 10.1088/0031-9155/55/11/017.Peer-Reviewed Original ResearchConceptsCerebral blood flowPrimary motor cortexCerebral blood volumeFunctional MRIMotor cortexAverage cerebral blood flowBlood oxygenation level-dependent (BOLD) signalCerebral metabolic rateLevel-dependent signalNeurovascular couplingBlood flowBlood volumeBOLD changesFMRI measurementsHypercapniaCortexMain target regionMetabolic rateGroup averagesActivation mapsCMRO2Physiological componentsFinger
1999
Motion Opponency in Visual Cortex
Heeger D, Boynton G, Demb J, Seidemann E, Newsome W. Motion Opponency in Visual Cortex. Journal Of Neuroscience 1999, 19: 7162-7174. PMID: 10436069, PMCID: PMC6782843, DOI: 10.1523/jneurosci.19-16-07162.1999.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingVisual motion perceptionMotion opponencyMotion perceptionVisual cortexSecondary visual cortical areasHuman MT complexHuman visual cortexDirection-selective signalsVisual cortical areasSensitive brain areasPrimary visual cortexMacaque monkey brainMagnetic resonance imagingPopulations of neuronsMultiunit electrophysiological recordingsBrain activityPerceptual studiesNeuronal correlatesFMRI measurementsArea MTCortical areasBrain areasMonkey brainResonance imaging
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