2023
Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie International Edition 2023, 62: e202307020. PMID: 37920913, DOI: 10.1002/anie.202307020.Peer-Reviewed Original ResearchConceptsInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsImmune checkpoint blockade therapyInhibition of autophagyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyMetastatic tumorsAutophagy inhibitionTreatment modalitiesMetal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Gu C, Liu X, Luo L, Chen J, Zhou X, Chen G, Huang X, Yu L, Chen Q, Yang Y, Yang Y. Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance. Angewandte Chemie 2023, 135 DOI: 10.1002/ange.202307020.Peer-Reviewed Original ResearchInduce immunogenic cell deathChemo-dynamic therapyMn-based catalystsExpression of autophagy-associated proteinsFenton-like reactionAutophagy-associated proteinsInhibition of autophagyImmune checkpoint blockade therapyCancer cellsSelf-protective pathwaysBilateral tumor modelCheckpoint blockade therapyImmunogenic cell deathSelf-protective mechanism of cancer cellsEffective treatment modalityHydroxyl radicalsHighest hydroxyl radicalInhibit tumor metastasisMechanism of cancer cellsKill cancer cellsIn vivo modelsBlockade therapyAutophagy inhibitionMetastatic tumorsTreatment modalities
2020
Aerobic oxidation of arsenite to arsenate by Cu( ii )–chitosan/O 2 in Fenton-like reaction, a XANES investigation
Pincus L, Gonzalez I, Stavitski E, Zimmerman J. Aerobic oxidation of arsenite to arsenate by Cu( ii )–chitosan/O 2 in Fenton-like reaction, a XANES investigation. Environmental Science Water Research & Technology 2020, 6: 2713-2722. DOI: 10.1039/d0ew00326c.Peer-Reviewed Original ResearchFenton-like reactionK-edge XANESN-TiOCatalyzed Fenton-like reactionChitosan complexesCu K-edge XANESFenton-like oxidationLoading of CuHigh loadingOxidation of arseniteCoordinate bondingCationic behaviorAerobic oxidationInorganic moleculesMechanism of CuAmine groupsXANES investigationChitosan backboneSimultaneous oxidationDissolved oxygenOxidationO 2ChitosanArsenic oxidationXANES
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