2025
Decoding cattle (Bos taurus) diacylglycerol acyltransferase (DGAT) gene families: A pathway to functional understanding
Esfahani E, Mahyari S, Davoodi P, Ghaderi-Zefrehei M, Lesch B. Decoding cattle (Bos taurus) diacylglycerol acyltransferase (DGAT) gene families: A pathway to functional understanding. Journal Of Heredity 2025, esae079. PMID: 39932434, DOI: 10.1093/jhered/esae079.Peer-Reviewed Original ResearchDiacylglycerol acyltransferaseGene familyDGAT genesComprehensive in silico analysisGene duplication eventsProduction traitsBos taurusFatty acyl-CoAsGene family membersMilk production traitsSNP locationsCattle genomeDuplication eventsAmino acid compositionDiacylglycerol acyltransferase proteinsDGAT2 geneExon countsAcyl-CoAImportant traitsMilk fat yieldMilk fat productionMilk fat synthesisSilico analysisFunctional SNPsGenetic makeup
2002
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*. Journal Of Biological Chemistry 2002, 277: 50230-50236. PMID: 12006582, DOI: 10.1074/jbc.m200958200.Peer-Reviewed Original ResearchConceptsIRS-1 tyrosine phosphorylationInsulin receptor substrate-1PI3-kinase activityReceptor substrate-1IRS-1Tyrosine phosphorylationSubstrate-1Insulin activationIRS-1-associated PI3-kinase activityInsulin-stimulated IRS-1 tyrosine phosphorylationInsulin-stimulated glucose transport activityProtein kinase CGlucose transport activityFatty acidsLipid infusionFatty acyl-CoAsDAG concentrationKinase CTransport activityPKC-thetaPhosphorylationIntracellular ceramideAcyl-CoAsTime-dependent fashionPhosphatidylinositol
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