2011
Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice
Kim M, Kay D, Rudra R, Chen B, Hsu N, Izumiya Y, Martinez L, Spencer M, Walsh K, Grinnell A, Crosbie R. Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Human Molecular Genetics 2011, 20: 1324-1338. PMID: 21245083, PMCID: PMC3049356, DOI: 10.1093/hmg/ddr015.Peer-Reviewed Original ResearchConceptsMdx miceMyofiber regenerationMuscular dystrophyTreatment of mdx miceDystrophin-deficient mdx miceMuscle functionEndogenous compensatory mechanismsExtensor digitorum longus muscleChildhood muscular dystrophyWild-type musclesDuchenne muscular dystrophyResponse relative to controlsGrip strength testImprove muscle functionAkt Signaling PathwayDystrophin-glycoprotein complexDystrophin deficiencyOverexpression of AktExtrasynaptic sarcolemmaMuscle wastingHistopathological measurementsDystrophin geneMdxRelative to controlsMuscle degeneration
2000
Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise
Ren J, Barucci N, Marshall B, Hansen P, Mueckler M, Shulman G. Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise. AJP Endocrinology And Metabolism 2000, 278: e588-e592. PMID: 10751190, DOI: 10.1152/ajpendo.2000.278.4.e588.Peer-Reviewed Original ResearchConceptsTg miceMuscle glycogen concentrationNT miceTransgenic miceGlycogen concentrationH postexerciseEDL musclesGastrocnemius muscleMuscle glycogenExtensor digitorum longus muscleMale transgenic miceIsolated EDL musclesAge-matched littermatesDigitorum longus muscleMuscle glycogen synthase activationMuscle glycogenesisLongus muscleMuscle glycogenolysisGLUT-1 proteinSynthase activationMicePostexerciseHuman GLUT-1GLUT-1Glycogen synthase activation
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