SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
Li L, Wang H, Zhang J, Sha Y, Wu F, Wen S, He L, Sheng L, You Q, Shi M, Liu L, Zhou H. SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition. Cell Death & Differentiation 2019, 27: 1924-1937. PMID: 31827236, PMCID: PMC7244772, DOI: 10.1038/s41418-019-0471-x.Peer-Reviewed Original ResearchConceptsActivation of activating transcription factor 6Mitochondrial permeability transitionApoptosis signal-regulating kinase 1SphK1 deficiencyER stressPermeability transitionEndoplasmic reticulumLevels of activating transcription factor 4Inhibit mitochondrial permeability transitionTranscription factor 6Transcription of inflammatory genesGlycogen synthase kinase 3bSignal-regulated kinases 1Transcription factor 4Phosphorylation of JNKAcetylation of p65Levels of histone deacetylaseHistone deacetylasesSphingosine-1-PhosphateImpaired phosphorylationKinase 1Factor 2AFactor 6Exogenous S1PSphK1
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