2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2017
ΔN-Bcl-xL, a therapeutic target for neuroprotection
Park HA, Jonas EA. ΔN-Bcl-xL, a therapeutic target for neuroprotection. Neural Regeneration Research 2017, 12: 1791-1794. PMID: 29239317, PMCID: PMC5745825, DOI: 10.4103/1673-5374.219033.Peer-Reviewed Original ResearchΔN-BclNeuronal deathNeuronal viabilityMitochondrial dysfunctionPrimary hippocampal neuronsABT-737Excitotoxic injuryGlutamate toxicityHippocampal neuronsAnti-apoptotic proteinsTherapeutic targetB cellsPrimary neuronsNeuronal functionAcute productionNeuroprotectionAltered metabolismMitochondrial damageNeuronsCentral targetMitochondrial functionDysfunctionDeathMitochondrial anti-apoptotic proteinDependent effects
1999
Changes in the Diffusion of Water and Intracellular Metabolites after Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain
Dijkhuizen R, de Graaf R, Tulleken K, Nicolay K. Changes in the Diffusion of Water and Intracellular Metabolites after Excitotoxic Injury and Global Ischemia in Neonatal Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 341-349. PMID: 10078886, DOI: 10.1097/00004647-199903000-00012.Peer-Reviewed Original ResearchConceptsNeonatal rat brainMetabolite apparent diffusion coefficientsGlobal ischemiaApparent diffusion coefficientADC dropExcitotoxic injuryRat brainN-methyl-D-aspartate (NMDA) injectionAcute cerebral ischemiaDiffusion-weighted magnetic resonance imagingBrain metabolite levelsMagnetic resonance imagingBrain temperature changesTissue deoxygenationCerebral ischemiaNMDA injectionContralateral valuesCytotoxic edemaMetabolites taurineBrain tissue waterN-acetylaspartateIschemiaWater apparent diffusion coefficientResonance imagingEarly alterations
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