Identification of Multiple Structurally Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method
Jamali H, Khan HA, Stringer JR, Chowdhury S, Ellman JA. Identification of Multiple Structurally Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method. Journal Of The American Chemical Society 2015, 137: 3616-3621. PMID: 25742366, PMCID: PMC4447334, DOI: 10.1021/jacs.5b00095.Peer-Reviewed Original ResearchConceptsProtein arginine deiminasesExhibit tissue-specific expressionTissue-specific expressionNonpeptidic small-molecule inhibitorsFamily of enzymesSmall molecule inhibitorsDistinct inhibitorsArginine residuesMolecule inhibitorsPAD inhibitorsArginine deiminasesLow molecular weightPAD3Selective inhibitorPotent inhibitorReliable discoveryInhibitorsMolecular weightFragment method
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