2021
Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia
Michael Deans P, Brennand K. Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia. Current Opinion In Neurobiology 2021, 69: 193-201. PMID: 34010781, PMCID: PMC8387340, DOI: 10.1016/j.conb.2021.04.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell type-specific fashionStem cell biologyType-specific fashionDisease-Associated VariantsNeural cell typesCommon genetic variantsMore genesCell biologyCRISPR engineeringGene manipulationGene targetsCRISPR technologyMolecular geneticsInvaluable advancesCell typesHiPSC technologyGenetic variantsStem cellsIndividual variantsEtiology of diseasePolygenic disorderVariantsComplex interactionsRecent advancesEtiology of schizophrenia
2020
Modeling factors affecting age, period and cohort trends
Holford T. Modeling factors affecting age, period and cohort trends. 2020, 117-141. DOI: 10.4324/9780429056819-7.Peer-Reviewed Original ResearchAnalytical epidemiological studiesUnderstanding of etiologyCigarette smokingLung cancerEtiology of diseaseEpidemiological studiesCarcinogenesis modelDisease trendsCohort scaleCohort frameworkHealth careDiseaseExposure dataPopulation ratesCohort modelCohort trendsSmokingAgeEtiologyU.S. malesTemporal trendsEarly stepsCancerPeriodCare
2019
The decreasing predictive power of MELD in an era of changing etiology of liver disease
Godfrey EL, Malik TH, Lai JC, Mindikoglu AL, Galván NTN, Cotton RT, O'Mahony CA, Goss JA, Rana A. The decreasing predictive power of MELD in an era of changing etiology of liver disease. American Journal Of Transplantation 2019, 19: 3299-3307. PMID: 31394020, DOI: 10.1111/ajt.15559.Peer-Reviewed Original ResearchConceptsMELD scoreLiver diseaseNon-alcoholic fatty liver diseaseHCV-positive patientsHCV-positive statusLab-MELD scoreAlcoholic liver diseaseFatty liver diseaseBest supportive therapyDe-identified dataLiver transplantLiver transplantationMELD eraFailure etiologyWaitlist deathsSupportive therapyUnited NetworkEtiology of diseaseOrgan SharingConcordance statisticDiseaseMortalityEtiologyMELDPatients
2017
LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data
Koelmel J, Kroeger N, Ulmer C, Bowden J, Patterson R, Cochran J, Beecher C, Garrett T, Yost R. LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data. BMC Bioinformatics 2017, 18: 331. PMID: 28693421, PMCID: PMC5504796, DOI: 10.1186/s12859-017-1744-3.Peer-Reviewed Original ResearchConceptsLipid identificationNumerous biological functionsHigh-resolution tandem mass spectrometry dataMass spectrometry workflowsUncharacterized adductsBiological functionsLipid typeStructural detailsLipid-based biomarkersPathway perturbationsTandem mass spectrometry dataSpectral similarity scoreCorrect annotationLipid speciesMass spectrometry dataLiquid chromatography-tandem mass spectrometry (LC-MS/MS) workflowSilico FragmentMass spectrometry experimentsLipid candidatesEtiology of diseaseLipid moleculesAnnotationFatty acyl constituentsBiomarker discoveryDisease etiology
2011
Morbidity and mortality after hepatic and pancreatic resections: results from one surgeon at a low-volume urban hospital over thirty years
Schwartz G, Swan R, Ruangvoravat L, Attiyeh F. Morbidity and mortality after hepatic and pancreatic resections: results from one surgeon at a low-volume urban hospital over thirty years. The American Journal Of Surgery 2011, 201: 438-444. PMID: 21421096, DOI: 10.1016/j.amjsurg.2010.10.005.Peer-Reviewed Original ResearchConceptsPancreatic resectionHepatic resectionSurgeon trainingLow-volume centersLow-volume institutionsAdequate surgeon trainingLow-volume hospitalsCentral pancreatectomyExtended lobectomyWedge resectionDistal pancreatectomyRetrospective reviewSurrogate markerResectionHospital volumeMorbidityUrban hospitalsEtiology of diseaseEtiologyMortalitySurgeonsLobectomyPancreatectomyNational databasePerioperative systemCentral nervous system complications of HIV infection.
Spudich SS, Ances BM. Central nervous system complications of HIV infection. Topics In Antiviral Medicine 2011, 19: 48-57. PMID: 21868822, PMCID: PMC6148949.Peer-Reviewed Original ResearchConceptsNervous systemCentral nervous system complicationsNervous system complicationsEarly treatment interventionStudy of pathogenesisCentral nervous systemBiomarkers of HANDDisease activityAdjunctive therapyNeurologic injuryHIV infectionOpportunistic infectionsSystem complicationsNeurologic disordersNeurocognitive disordersEtiology of diseaseMeasurable biomarkersEarly infectionTreatment interventionsInfectionHIVBiomarkersDisordersTreatmentNovel molecules
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