The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3
Okalang U, Bar-Ner B, Rajan K, Friedman N, Aryal S, Egarmina K, Hope R, Khazanov N, Senderowitz H, Alon A, Fass D, Michaeli S. The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3. MBio 2021, 12: e02602-21. PMID: 34844425, PMCID: PMC8630539, DOI: 10.1128/mbio.02602-21.Peer-Reviewed Original ResearchConceptsSpliced leader RNA silencingER oxidoreductin 1Quiescin sulfhydryl oxidaseER-resident chaperone BiPMitochondrial protein importEndoplasmic reticulumProtein importChaperone BiPRNA silencingSpliced leader (SL) RNACausative agent of human African sleeping sicknessSulfhydryl oxidasePerturbation of endoplasmic reticulumSL RNA transcriptionInduction of programmed cell deathHuman African sleeping sicknessATP-binding domainPotential novel drug targetsParasite Trypanosoma bruceiSerine-threonine kinaseNovel drug targetsProtein sortingAfrican sleeping sicknessProtein translocationPhosphorylation events
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