Chiral N-Acyl-tert-butanesulfinamides: The “Safety-Catch” Principle Applied to Diastereoselective Enolate Alkylations
Backes BJ, Dragoli DR, Ellman JA. Chiral N-Acyl-tert-butanesulfinamides: The “Safety-Catch” Principle Applied to Diastereoselective Enolate Alkylations. The Journal Of Organic Chemistry 1999, 64: 5472-5478. PMID: 11674609, DOI: 10.1021/jo990271w.Peer-Reviewed Original ResearchAlkylation reactionDiastereoselective C-alkylationSolid-phase synthesisDiastereoselective enolate alkylationTarget compoundsN-alkylationChiral alcoholsChiral auxiliariesEnantiopure productsC-alkylationEnolate alkylationSulfinamidesButanesulfinamidesAlkylation productsHigh diastereoselectivityS-oxidationEster equivalentsCompoundsAcylationReactionAuxiliariesConversionSafety catchChiralAlkylation
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