Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo J, Su Y, Zhong C, Ming G, Song H. Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain. Cell 2011, 145: 423-434. PMID: 21496894, PMCID: PMC3088758, DOI: 10.1016/j.cell.2011.03.022.Peer-Reviewed Original ResearchConceptsActive DNA demethylationDNA demethylationMammalian cellsHydroxylation of 5-methylcytosineMammalian genomic DNABase excision repair pathwayPromoter DNA demethylationHuman DNA glycosylasesExcision repair pathwayAdult mouse brain in vivoCytosine methylationEpigenetic marksTranscriptional regulationGenomic DNADNA glycosylaseRepair pathwaysCovalent modificationGene expressionMolecular mechanismsActivity-inducedCytidine deaminaseEnzymatic removalDemethylationTET1Mouse brain in vivo
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