A Method for the Acute and Rapid Degradation of Endogenous Proteins
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, Schuh M. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell 2017, 171: 1692-1706.e18. PMID: 29153837, PMCID: PMC5733393, DOI: 10.1016/j.cell.2017.10.033.Peer-Reviewed Original ResearchConceptsTrim-AwayProtein functionSystematic characterization of genesDisruption of protein functionEndogenous proteinsStudy of protein functionCharacterization of genesDisrupt protein functionCellular protein degradation machineryProtein degradation machineryEndogenous protein levelsDiverse cell typesDegradation of endogenous proteinsDegradation machineryMammalian cellsRNA interferenceTarget proteinsNative proteinTargeted disruptionGenomeCell typesProteinPrimary cellsRapid degradationProtein levels
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply