Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases
Roychoudhury P, De Silva Feelixge H, Pietz H, Stone D, Jerome K, Schiffer J. Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases. Journal Of Antimicrobial Chemotherapy 2016, 71: 2089-2099. PMID: 27090632, PMCID: PMC4954920, DOI: 10.1093/jac/dkw104.Peer-Reviewed Original ResearchConceptsVector serotypeViral vectorsDose selectionAnti-HIV gene therapyHIV-infected cellsEngineered viral vectorsGene therapy applicationsDose-response relationshipFunctional cureGene expressionGene therapyReporter geneSigmoid dose-response relationshipTransduction efficiencyCurative approachViral uptakeTherapeutic outcomesTarget cellsIndividual target cellsDoseExpress transgenesVirus replicationTherapy applicationsLatent genomesActivation of endonucleases
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply