2018
Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons
Wang P, Zhao D, Lachman HM, Zheng D. Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons. Translational Psychiatry 2018, 8: 13. PMID: 29317598, PMCID: PMC5802446, DOI: 10.1038/s41398-017-0058-6.Peer-Reviewed Original ResearchConceptsASD candidatesEnriched expressionSingle-cell transcriptomic dataSingle-cell transcriptome profilesCo-expression gene modulesDifferent developmental stagesExcitatory/inhibitory (E/I) imbalance hypothesisInhibitory neuronsGene networksTranscriptome profilesGene modulesTranscriptomic dataUpregulated genesDownstream targetsGene expressionDevelopmental stagesCell typesGenesNeuron subtypesFunctional evidenceAutism spectrum disorderExpressionASD brainCortex samplesExcitatory neurons
2003
Nuclear and cytosolic calcium are regulated independently
Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumCalcium ChannelsCell LineCell MembraneCell NucleusCytosolDose-Response Relationship, DrugEndoplasmic ReticulumHumansImmunoblottingImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLipid BilayersMicroscopy, ConfocalProtein IsoformsReceptors, Cytoplasmic and NuclearSignal TransductionTime FactorsConceptsEndoplasmic reticulumImportant cellular processesType II isoformCellular processesCellular compartmentsGene transcriptionEnriched expressionNuclear calciumTrisphosphate receptorIndependent regulationCytosolLiver cell lineCell linesHepG2 liver cell lineSubcellular mechanismsReticulumNucleus resultsDependent processesCytosolic calciumNucleusTranscriptionType ISignalingIsoformsSimilar extent
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