2021
Emerging roles of PLCγ1 in endothelial biology
Chen D, Simons M. Emerging roles of PLCγ1 in endothelial biology. Science Signaling 2021, 14 PMID: 34344833, PMCID: PMC8507396, DOI: 10.1126/scisignal.abc6612.Peer-Reviewed Original ResearchConceptsUnique protein structurePhospholipase C-γ1Receptor tyrosine kinasesRole of PLCγ1Major physiological roleMolecular functionsDistinct vascular phenotypePLC familyC-γ1Signal transducerProtein structureDirect effectorTyrosine kinaseMembrane lipidsSecond messengerFunction mutationsPhysiological rolePLCγ1Endothelial biologyEndothelial cancerCritical roleVascular phenotypeEndothelial cellsKinaseFuture investigations
2007
Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells
Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells. Circulation Research 2007, 100: 1164-1173. PMID: 17379831, DOI: 10.1161/01.res.0000265065.26744.17.Peer-Reviewed Original ResearchConceptsGene expressionHuman endothelial cellsEndogenous miRNA levelsImportance of miRNAsMaturation of microRNAsEC gene expressionEndothelial cellsTek/TieKnockdown of DicerDICER-dependent microRNAsRole of DicerMiRNA expression profilesKDR/VEGFR2MiR-222/221Dicer knockdownDependent microRNAsSynthase protein levelsDicerKey regulatorExpression profilesKey enzymePhysiological pathwaysCord formationEndothelial biologyMiRNAs
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