2018
Tight junction structure, function, and assessment in the critically ill: a systematic review
Vermette D, Hu P, Canarie MF, Funaro M, Glover J, Pierce RW. Tight junction structure, function, and assessment in the critically ill: a systematic review. Intensive Care Medicine Experimental 2018, 6: 37. PMID: 30259344, PMCID: PMC6158145, DOI: 10.1186/s40635-018-0203-4.Peer-Reviewed Original ResearchCritical illnessSystematic reviewTight junctionsGut bacterial translocationMultiple organ failureFull-text reviewEndothelial tight junctionsEndothelial barrier integrityCritical disease statesTJ structureBacterial translocationCardiac failureClinical outcomesOrgan failurePulmonary edemaBarrier disruptionPROSPERO databaseResultsA totalBarrier dysfunctionPulmonary pathologyTherapeutic advancesCapillary leakInclusion criteriaGastrointestinal epitheliumTJ breakdown
2013
CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism
Flynn KM, Michaud M, Canosa S, Madri JA. CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism. Angiogenesis 2013, 16: 689-705. PMID: 23504212, DOI: 10.1007/s10456-013-9346-9.Peer-Reviewed Original ResearchConceptsEndothelial cellsVascular permeabilityPlatelet endothelial cell adhesion molecule-1 expressionCell adhesion molecule-1 expressionAdhesion molecule-1 expressionDependent mechanismCD44 KO miceEndothelial cell adhesion molecule-1 expressionVascular endothelial barrier integrityLoss of CD44Molecule-1 expressionMatrix metalloprotease expressionCD44-deficient miceVascular barrier functionEndothelial junction proteinsEndothelial barrier integrityProlonged permeabilityC57BL/6 WTVasoactive challengeWT statusBarrier integrityWT counterpartsVascular integrityEvans blueBarrier function
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