5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors 1
Mukhin A, Gündisch D, Horti A, Koren A, Tamagnan G, Kimes A, Chambers J, Vaupel D, King S, Picciotto M, Innis R, London E. 5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors 1. Molecular Pharmacology 2000, 57: 642-649. DOI: 10.1016/s0026-895x(24)26432-4.Peer-Reviewed Original ResearchAffinity of epibatidineMuscle-type nAChRsBinding to nAChRsSlow rate of dissociationRate of dissociationReceptor-ligand complexesNeuronal nicotinic acetylcholine receptorsSubtype-selective ligandsNAChR subtypesEpibatidineA4B2K d valuesNicotinic acetylcholine receptorsNAChRsSubunits of nAChRsRat adrenal glandAffinityBrain regionsLigandDissociationCompoundsBindingAcetylcholine receptorsIn vivo studiesHuman brain5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors
Mukhin A, Gündisch D, Horti A, Koren A, Tamagnan G, Kimes A, Chambers J, Vaupel D, King S, Picciotto M, Innis R, London E. 5-Iodo-A-85380, an α4β2 Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors. Molecular Pharmacology 2000, 57: 642-649. PMID: 10692507, DOI: 10.1124/mol.57.3.642.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsAlpha4beta2 nAChRsAcetylcholine receptorsNeuronal nicotinic acetylcholine receptorsAffinity of epibatidineRat adrenal glandMuscle-type nAChRsSubtype-selective ligandsAlpha4beta2 subtypeAdrenal glandRat brainSelective radioligandBrain regionsNAChRsBeta4 subunitsRadioiodinated ligandBeta2 subunitVivo studiesEpibatidineVivo experimentsHuman brainSubtypesRadioligandBrainReceptors
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