Efficient Genome Editing Using ‘NanoMEDIC’ AsCas12a-VLPs Produced with Pol II-Transcribed crRNA
Borovikova S, Shepelev M, Mazurov D, Kruglova N. Efficient Genome Editing Using ‘NanoMEDIC’ AsCas12a-VLPs Produced with Pol II-Transcribed crRNA. International Journal Of Molecular Sciences 2024, 25: 12768. PMID: 39684477, PMCID: PMC11641575, DOI: 10.3390/ijms252312768.Peer-Reviewed Original ResearchRNA ribonucleoprotein complexVirus-like particlesGenome editingProcesses pre-crRNARNA polymerase IIIEfficient genome editingTargeted genome editingJurkat T cellsGene therapy applicationsMature crRNAsPre-crRNAPolymerase IIICas nucleasesRibonucleoprotein complexEfficient targeted genome editingCrRNAMammalian cellsLevels of gene editingPackaging mechanismPromoter usageU6 promoterT cellsEditing efficiencyCXCR4 knockoutGene editing
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